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A retrospective cohort study to evaluate the effectiveness and safety profile of occipital nerve blocks in the treatment of migraine during pregnancy

Liza Smirnoff, Leon S. Moskatel, Blake Shaw, Zi-Huai He, A. Peretz

Headache, 2025

5 citations

Abstract

Nearly 12% of Americans experience migraine, with 75% of that group represented by women aged 15–55 years, notably including peak childbearing years. This presents a therapeutic dilemma for pregnant patients, given that most medications for migraine range from unknown teratogenicity in human pregnancies, at best, to known teratogenicity, severely limiting their utility. However, migraine causes significant disability and impairment in the lives of pregnant patients, necessitating treatment. We conducted a retrospective chart review and phone survey to evaluate the safety profile and effectiveness of bilateral occipital nerve blocks to treat migraine during pregnancy.

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