Evaluation of posterior ocular structures in pediatric migraine patients with and without aura
Abstract
BACKGROUND: To conduct a quantitative assessment of choroidal structural parameters obtained from pediatric migraine patients (Ped-MPs) with aura (A+) and without aura (A-).
METHODS: This prospective, case-control structured research was performed among the Ped-MPs in the Ped-MP Group and non-migraine pediatric healthy patients (Ped-HP Group). Choroidal structural parameters were compared between the groups, including five-point choroidal thickness (Ch-T), total choroidal area (TA), luminal choroidal area (LA), stromal choroidal area (SA), and choroidal vascular index (CR-VI). The patients were then also divided further into two groups, as those with aura (A+) and without aura (A-).
RESULTS: The Ped-MP Group was made up of 43 participants, while there were 47 participants in the Ped-HP Group. No significant difference was seen between these two groups with respect to age and sex (p > 0.05). No difference was observed between these groups in the Ch-T measurements taken from 5 points. While no change was observed in the SA between the groups, a significant increase was found in the TA, LA, and CR-VI in the Ped-MP Group (for all of them: p < 0.05).
CONCLUSIONS: Choroidal thickening, and increased TA, LA, and CR-VI were just a few of the structural changes that were associated with migraine, and these changes were seen to become more pronounced in the Ped-MP A+ Group.
How strong is the evidence?
Evidence Hub reads this as a case-control, done in people. Its evidence level is 4 of 5 (Low · observational). Observational designs can show an association but not prove cause. Reported size: 47 participants or records.
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