Vestibular migraine vs. migraine only: integrated transcriptome-clinical profiling reveals shared inflammation and divergent metabolic pathways for targeted therapy
Abstract
BACKGROUND: Vestibular migraine (VM) is often considered a subtype of migraine, but the pathogenesis of both has not been fully elucidated. The aim of this study is to integrate clinical data systems through transcriptome sequencing to explore the similarities and differences between the two in terms of pathogenesis and clinical manifestations and predict therapeutic drugs.
METHODS: This study included 9 cases of VM, 6 cases of migraine only (MO), and 14 healthy controls (HC). Detailed records were kept of each participants basic information and clinical characteristics related to their onset of illness, with statistical analysis conducted using R. Additionally, peripheral blood mononuclear cells (PBMCs) from each participant were collected for high-throughput RNA sequencing. Next, DEseq2 packages were used to identify differentially expressed genes (DEGs) between MO/HC, VM/HC, and VM/MO. Pearson correlation was used to calculate co-expressed genes between MO/HC and VM/HC, and gene sets were functional annotation and pathway enrichment analysis. Furthermore, hub genes were screened using protein interaction and Cytoscapes Degree algorithm, and further evaluation was conducted using transcriptome data. Finally, common therapeutic drugs were predicted using DGIdb, Drugbank, and ClinicalTricals.
RESULTS: Compared to HC, both VM and MO patients exhibited higher incidences of anxiety, depression, and sleep disorders, with overlapping triggers and symptoms. However, VM patients…
How strong is the evidence?
Evidence Hub reads this as a case-control, done in people. Its evidence level is 4 of 5 (Low · observational). Observational designs can show an association but not prove cause.
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