Electroencephalographic Resting-State Microstates are Unstable in Visual Snow Syndrome
Abstract
OBJECTIVE: To study large-scale network processing in visual snow syndrome (VSS) with and without migraine, we applied resting-state electroencephalographic microstate analysis.
BACKGROUND: VSS is characterized by a spectrum of visual symptoms, with the main symptom being perceived as flickering dots throughout the visual field. The syndrome is associated with migraine and tinnitus and is considered a network disorder, but the cause and pathophysiology are still largely unknown.
METHODS: In this case-control study, resting-state electroencephalography (EEG) recordings were selected from a cohort of 21 subjects with VSS (8 females, 33 ± 9.56 years, 14 migraines) and 21 matched controls (8 females, 33 ± 11.1 years, 14 migraines). An analysis of parameters between the four canonical microstate Classes A-D was performed.
RESULTS: VSS patients showed an overall shorter duration (p = 0.001, Cohen's d = -0.48) and lower mean amplitude (p < 0.001, Cohen's d = -0.76) of microstates compared to the controls. In addition, we found an aberrant syntax of microstate Class A (auditive and visual processing) with more (p = 0.001, Cohen's d = 0.57) transitions to Class B (visual) and less (p = 0.011, d = -0.71) to Class C (interoceptive, salience) compared to controls.
CONCLUSION: Visual snow syndrome (VSS) is a complex disorder, affecting widespread neural network activity. In VSS, electroencephalography (EEG) microstate analysis revealed unstable microstates as well as aberrant transition…
How strong is the evidence?
Evidence Hub reads this as a case-control, done in people. Its evidence level is 4 of 5 (Low · observational). Observational designs can show an association but not prove cause. Reported size: 21 participants or records.
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