Abstract P248: Women With Migraine Had Higher Progression of 10-year Stroke Risk Than Those Without Migraine: Findings From a Nested Case-Control Study
Abstract
Introduction:
There was limited understanding of the association between migraine status and longitudinal changes in stroke risk.
Hypothesis:
We hypothesized that migraine patients would have higher growth in 10-year stroke risk than those without migraine during a 1-year follow-up period in Hong Kong Chinese women.
Methods:
A nested case-control study was conducted using data from the Migraine Exposures and Cardiovascular Health in Hong Kong Chinese Women (MECH-HK). The MECH-HK initially enrolled 4,221 Hong Kong Chinese women aged 30-74 years between 2019 and 2021 and followed up with 3,435 participants in the second-round survey until September 2023. Diagnosis of migraine was confirmed according to the ICHD-3 criteria. Stroke risk was calculated using the 10-year China-PAR (Prediction for Atherosclerotic Cardiovascular Disease Risk in China) stroke risk model. The change in China-PAR stroke risk between the baseline and second-round survey was then computed. Cases were identified as individuals with the top 20% high growth in China-PAR stroke risk. The age-matched controls (±2 years) were randomly selected from the cohort at a 1:1 ratio. The odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using multivariable conditional logistic regression models. Subgroup analyses were performed based on participants' baseline age (<65 years or ≥65 years) and the presence of migraine aura (migraine with or without aura).
Results:
A total of 589 cases (aged 60.70 ±…
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