A randomized case-control study on plasma serotonin, nitric oxide and frequency of migraine attacks in patients, on practice of integrated amrita meditation (IAM) technique
Abstract
Objective Methods We focused on the effect of IAM technique on frequency of migraine attacks and neurotransmitters.
Patients were randomly divided in to IAM and control groups (n = 39 each) using table of random numbers. The
frequency of migraine attacks, neurotransmitter levels were assessed at baseline, 3 months, and 6 months of IAM practice regularly. A Results
reduction in the frequency of migraine signicantly was found in the IAM group after 3 months, which sustained for 6 months (p value =0.000)
whereas in the control group signicant change was not seen. The changes seen in IAM group were statistically signicant when compared to the
control group after 3 and 6 months (p = 0.065, 0.005). Within IAM group there was an increase in the differences in mean values of plasma levels
of serotonin after 3 and 6 months (p =0.001 and 0.002) and decrease in nitric oxide (NO) after 3 and 6 months (p value 0.000). In the control group,
there was a signicant decrease in the mean values of serotonin (p value0.003 and 0.001) and increase in NO levels after 6 months (p 0.034). When
the two groups were compared, there was signicant difference between groups in serotonin (p =0.000 and 0.001) and NO values (p value 0.000).
Conclusion Our study proved that practice of IAM technique regularly can decrease the migraine frequency with increase in serotonin and
decrease in nitric oxide levels signicantly.
How strong is the evidence?
Evidence Hub reads this as a randomized trial, done in people. Its evidence level is 2 of 5 (High · randomized trial). Randomized trials of a reasonable size are the strongest single-study design. Reported size: 39 participants or records.
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