Serum Otolin-1 and Otoconin-90 are not elevated in vestibular migraine: a preliminary case-control study
Abstract
Objective Vestibular migraine (VM) is a common cause of episodic vertigo but lacks objective diagnostic biomarkers. The symptomatic overlap of VM with benign paroxysmal positional vertigo (BPPV) and Meniere’s disease (MD) complicates differential diagnosis. Given that elevated serum Otolin-1 and Otoconin-90 (OC90) levels are established biomarkers in BPPV and MD, this study aimed to determine whether these otoconia-derived proteins are also altered in VM. Methods In this case-control study, 40 patients with definite VM and 143 age- and sex-matched healthy controls were included. Serum samples were collected during the interictal period. Otolin-1 and OC90 levels were quantified using enzyme-linked immunosorbent assays. Results No significant differences were found in serum levels of Otolin-1 and OC90 between groups. The median (IQR) Otolin-1 level was 215.5 pg/mL (127.5–314.9) in the VM group vs. 200.6 pg/mL (127.7–284.2) in controls (Cliff’s δ = 0.08, p = 0.526). Similarly, the median (IQR) OC90 level was 39.8 ng/mL (29.4–60.8) compared to 32.7 ng/mL (27.9–77.9) in controls (Cliff’s δ = −0.07, p = 0.659). No correlations were observed between protein levels and clinical features. However, within the VM group, serum Otolin-1 levels were highest within 1-week post-attack and declined thereafter, showing a significant negative correlation with time (r = −0.372, p = 0.018). A similar phase-dependent pattern was observed for OC90 levels across the VM subgroups (p = 0.017), though…
How strong is the evidence?
Evidence Hub reads this as a case-control. Its evidence level is 4 of 5 (Low · observational). Observational designs can show an association but not prove cause. Reported size: 40 participants or records.
Read the paper
Related studies
- Calcium Ions in the Physiology and Pathology of the Central Nervous System
- AI-powered in silico twins: redefining precision medicine through simulation, personalization, and predictive healthcare
- In silico functional, structural and pathogenicity analysis of missense single nucleotide polymorphisms in human MCM6 gene
- In Silico drug repurposing pipeline using deep learning and structure based approaches in epilepsy
- Targeting serotonin receptors with phytochemicals – an in-silico study
- In silico exploration of anti-prostate cancer compounds from differential expressed genes
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.