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Musculoskeletal impairments associated with migraine in young adults: a case-control study

Akshitha Rajasekhar, Vijayakumar Palaniswamy, H. S. Deepti, Jackson Shaji, Femina Ibrahim, Havas Muhammed, Shikha Mehra

Physiotherapy Theory and Practice, 2026

Abstract

BACKGROUND

Migraine is common among university students and is frequently associated with neck pain, postural alterations, and musculoskeletal dysfunction. Cervical musculoskeletal impairments may be clinically relevant because nociceptive input from the upper cervical region can converge with trigeminal pathways within the trigeminocervical complex, potentially contributing to pain sensitization in some individuals with migraine.

OBJECTIVE

To examine the association of core muscle endurance, cervical muscle endurance, and craniovertebral angle with migraine in university studentsand to determine whether these musculoskeletal variables remained associated with migraine status after accounting for age, sex, and body mass index.

METHODS

In this case-control study, 140 university students aged 18-28 years were recruited, including 70 with neurologist-confirmed migraine based on the International Classification of Headache Disorders, 3rd edition (beta version), and 70 headache-free controls. Core muscle endurance was assessed using the McGill endurance tests. Cervical flexor and extensor muscle endurance, as well as craniovertebral angle, were also measuredusing standardized procedures. Baseline characteristics were compared between groups. Between-group comparisons were performed using independent-samples t tests, and adjusted analyses were performed with age, sex, and body mass index entered as covariates. Predictors of migraine status were explored using logistic regression.…

How strong is the evidence?

Evidence Hub reads this as a case-control, done in people. Its evidence level is 4 of 5 (Low · observational). Observational designs can show an association but not prove cause.

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