Association of GABRA1 Polymorphisms with Migraine with Aura: A Preliminary Case–Control Study in a Turkish Cohort
Abstract
ABSTRACT Aim: The objective of this study is to ascertain the association between two prevalent GABRA1 polymorphisms (rs12658835, rs35166395) and migraine with aura . In addition, the investigation will encompass the clinical characteristics of the condition, including trigger patterns and family history. Material and Method: 108 persons with clinically proven migraine with aura and 107 demographically matched healthy controls were enrolled in a multicenter case-control study (Atatürk University Faculty of Medicine Neurology Department and Palandöken State Hospital Neurology Outpatient Clinic; 01 Feb–01 Jun 2013). Sociodemographics, migraine characteristics, triggers, and family history were recorded through structured in-person interviews. A sample of peripheral blood was used to extract genomic DNA. SNP genotyping was performed using a validated real-time PCR allelic discrimination kit for GABRA1 rs12658835 and rs35166395. The case/control status was hidden from the lab staff. Results: The migraine with aura cohort was predominantly female (82.4%) with a mean age of 33.8 ± 12.4 years; the control group exhibited a similar distribution of sex and age (both p > 0.05, Mann–Whitney U for age). rs12658835 exhibited an excess of mutant genotype in migraine with aura (7.4%, 8/108) in comparison to the control group (0%, 0/107), p = 0.007. The genotype distributions of rs35166395 (wild/mutant/heterozygous: 60/16/24% in migraine with aura vs. 65/13/22% in controls) did not differ…
How strong is the evidence?
Evidence Hub reads this as a case-control, done in people. Its evidence level is 4 of 5 (Low · observational). Observational designs can show an association but not prove cause.
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