Thiamine deficiency in patients with chronic migraine: A case–control study
Abstract
Thiamine deficiency is well recognized in several neurological disorders, and subclinical deficiency has been associated with nonspecific symptoms, including headache. However, thiamine deficiency is not currently recognized as a cause of headache in standard headache classifications. Chronic migraine (CM) is often accompanied by symptoms such as nausea, vomiting, and reduced appetite, which may influence nutritional intake and micronutrient status, including thiamine depletion. These factors raise the possibility of an interaction between migraine and thiamine status. Our objectives were to compare serum thiamine levels in patients with CM and matched healthy controls and to explore whether low thiamine levels are associated with CM and related clinical features.
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