Genetic Factors in Migraine with Aura in Argentina: An Exploratory Case-Control Study
Abstract
Migraine is a primary headache disorder with neurovascular involvement. Migraine with aura is a subtype that accounts for approximately 15%–40% of all migraine cases. Several studies have shown that the global prevalence of migraine varies depending on the population studied. The population of Buenos Aires Province has an admixed genetic background. Several genetic association studies on migraine have been reported; however, most of them were conducted in cohorts of European ancestry, introducing a bias that overlooks global population diversity. DNA was extracted from 310 samples (153 cases and 157 controls). Each donor rinsed his or her mouth with 1 ml of water, and this was the material from which we obtained DNA. So, it was obtained not only from saliva but also from cells coming from the buccal mucosa. Genotypes were determined using allele-specific polymerase chain reaction and polymerase chain reaction–restriction fragment length polymorphism techniques for the following polymorphisms: rs2075968 (PRDM16), rs12134493 (TSPAN2), rs10166942 (TRPM8), rs10456100 (KCNK5), rs4910165 (IRAG1), rs11031122 (MPPED2), rs11172113 (LRP1), and rs6081613 (SLC24A3). A case-control analysis was conducted using logistic regression models. All markers were in Hardy-Weinberg equilibrium in the case group. In the control group, however, rs4910165 (IRAG1) deviated from equilibrium and was therefore excluded from the association analysis (p = .0032). Although codominant and dominant models…
How strong is the evidence?
Evidence Hub reads this as a case-control. Its evidence level is 4 of 5 (Low · observational). Observational designs can show an association but not prove cause.
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