Deficient inhibition of irrelevant visual information in migraine: A magnetoencephalography study of alpha-band activity
Abstract
OBJECTIVES/BACKGROUND: There is growing evidence that migraine is associated with attentional abnormalities, both during and between attacks, potentially affecting the cognitive processing of sensory stimulation. However, the underlying neurophysiological mechanism remains poorly understood. This study aimed to investigate whether top-down and bottom-up attentional mechanisms, as indexed by alpha- and gamma-band oscillatory activity measured with magnetoencephalography are altered in patients with episodic migraine without aura during the interictal phase.
METHODS: In a cross-sectional study (conducted in 2016-2017 in Lyon area of France) with a comparison of matched groups, 19 patients with migraine without aura and 19 healthy participants performed an attentional task involving visually cued auditory targets and distracting sounds to evaluate conjointly top-down and bottom-up attention mechanisms. Magnetoencephalography was used to record anticipatory alpha activity (power increase and decrease) and distractor-induced gamma activity as markers for top-down (inhibition and facilitation) and bottom-up attention, respectively.
RESULTS: Compared to healthy participants, patients with migraine exhibited a significantly less prominent alpha power increase in visual areas in anticipation of the auditory target (permutation tests, cluster significance p = 0.043), indicating a reduced inhibition of task-irrelevant visual areas. In contrast, there was no significant group difference…
How strong is the evidence?
Evidence Hub reads this as a cross-sectional, done in people. Its evidence level is 4 of 5 (Low · observational). Observational designs can show an association but not prove cause. Reported size: 19 participants or records.
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