Systemic Inflammation and Oxidative Stress Markers in Patients With Medication Overuse Headache
Abstract
BACKGROUND: Recent scientific evidence has suggested that inflammation and oxidative stress may play a significant role in the pathogenesis of medication overuse headache (MOH). This study aims to investigate the differences in peripheral markers of systemic inflammation and oxidative stress, such as the monocyte to high-density lipoprotein (HDL) ratio (MHR), and their correlation with clinical symptoms in MOH patients, episodic migraine patients, and healthy controls.
METHODS: This cross-sectional study recruited MOH patients along with age- and sex-matched controls. Differences in indicators of inflammation and oxidative stress were compared across different groups, including MOH patients with different preexisting headache subtypes. Univariate and multivariate logistic regression analyses were employed to identify independent factors associated with the occurrence of MOH.
RESULTS: The study comprised 109 MOH patients, 68 episodic migraine patients, and 86 healthy controls. MOH patients exhibited significantly higher values of MHR, lymphocyte to HDL ratio (LHR), and neutrophil to HDL ratio (NHR) compared to healthy controls. No statistically significant differences in these indicators were observed between the MOH subgroups. Correlation analysis revealed that only the triglyceride-glucose index was negatively correlated with monthly headache days in MOH patients (r = -0.230, p = 0.016). Additionally, elevated values of MHR odds ratios ((OR) = 2.32, 95% confidence intervals…
How strong is the evidence?
Evidence Hub reads this as a cross-sectional, done in people. Its evidence level is 4 of 5 (Low · observational). Observational designs can show an association but not prove cause. Reported size: 109 participants or records.
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