Metabolic abnormalities in the insula of patients with interictal migraine without aura: a prospective cross-sectional study
Abstract
Background The insula plays a crucial role in the pathophysiology of patients with migraine without aura (MWoA), but the exact neurometabolic mechanisms are still unclear. This study aimed to explore possible neurometabolic mechanisms in the insula during the interictal period in MWoA patients, and neurometabolic differences between high frequency (HF) and law frequency (LF) headache patients via proton magnetic resonance spectroscopy (1H-MRS). Methods A total of 22 MWoA patients and 22 age-, gender-, and education-matched healthy controls (HCs) were included in this prospective cross-sectional study. The subjects underwent routine T1-weighted imaging (T1WI) and single-voxel 1H-MRS scans, with the region of interest fixed in the left insula. Metabolites, including myo-inositol (Ins), N-acetyl aspartate (NAA), choline-containing compound (Cho), creatine and phosphocreatine (Cr), glutamate and glutamine (Glx), were quantified via the linear combination model (LCModel) software, and then corrected for the partial volume effect of cerebrospinal fluid (CSF). The MWoA patients were categorized into LF and HF headache groups according to their headache frequency. Metabolic differences between the groups were tested by an analysis of covariance (ANCOVA), and the clinical relevance of these metabolites was analyzed by Pearson or Spearman correlation analyses. Results During the interictal period of headache, the Ins (MWoA vs. HCs: 5.16±1.14 vs. 6.21±1.14, P=0.017), NAA (MWoA vs. HCs:…
How strong is the evidence?
Evidence Hub reads this as a cross-sectional, done in people. Its evidence level is 4 of 5 (Low · observational). Observational designs can show an association but not prove cause. Reported size: 22 participants or records.
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