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Natural Neurostimulation for Chronic Pain Management: A Case Series of 3 Patients with Dysmenorrhea and Menstrual Migraine

I. V. Danilov, Dace Medne, S. Mihailova

OBM Neurobiology, 2025

Abstract

Accumulating evidence suggests that chronic pain occurs in various disorders due to correlated processes of spontaneous cortical reorganization and dysregulation of cortical excitability in consciousness-related networks. This case series tracks three patients with chronic pain associated with the menstrual cycle treated by a novel non-invasive brain stimulation technique that applies qualities of the mother-fetus neurocognitive model. Previous research has shown that a low-frequency pulsed electromagnetic field and a complex acoustic wave from the mother’s heart contribute to the synchronization of these two nervous systems, thereby developing a balanced nervous system in fetuses. Therefore, we hypothesize that the scaled parameters of these natural forces can be used to treat an injured nervous system in adults. Acoustic photonic intellectual neurostimulation (APIN) emulates the central parameters of this natural brain stimulation during pregnancy. Based on evidence from previous research, we suppose that weak stimulations with these therapeutic agents excite different neuronal networks in specific consciousness-related brain areas; their integrated impact modulates mitochondrial functions and causes neuronal tissue oxygenation and adenosine-5’-triphosphate protein release, leading to pain relief and facilitating neuronal plasticity. This sequence of physicochemical interactions produces a change in brain connectivity that supports a change in symptoms such as chronic…

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Evidence Hub reads this as a case series, done in people. Its evidence level is 5 of 5 (Very low · case / narrative / animal / in vitro / in silico). Case reports, narrative reviews, and animal, cell or computer-model studies give the weakest evidence for human health.

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