Migraine Surgery in India: Early Experience and Outcomes from a Pioneering Surgical Series
Abstract
Abstract Background Peripheral nerve decompression for focal migraine trigger sites has shown promising results internationally but has not been described previously as a clinical series from India. We report a case series of peripheral trigger site surgery performed in India. In this article, we describe our patient selection algorithm, operative techniques, and place our early outcomes in the context of contemporary evidence. Materials and Methods Between 2023 and 2025, five adult patients with neurologist-confirmed chronic, refractory migraine were retrospectively enrolled. Inclusion required a consistent, localizable “pain point” on history/exam, confirmed by handheld Doppler showing a pulsatile vessel. Surgeries targeted the supraorbital (frontal) zygomaticotemporal and auriculotemporal (temporal) trigger sites using established transpalpebral or temporal approaches. Outcomes were measured with migraine headache index (MHI) and migraine-free days per month at 6 to 24 months' follow-up. Results There was a reduction in MHI by 72%, with 80% patients reporting clinically significant improvement (≥ 50% reduction in frequency and/or severity). One patient noted mild improvement. There was an increase in migraine-free days by 124%. No intraoperative or postoperative complications were observed. Recovery was uneventful in all cases. Conclusion In carefully selected patients, peripheral trigger site surgery for migraine is feasible, effective, and safe in an Indian clinical…
How strong is the evidence?
Evidence Hub reads this as a case series, done in people. Its evidence level is 5 of 5 (Very low · case / narrative / animal / in vitro / in silico). Case reports, narrative reviews, and animal, cell or computer-model studies give the weakest evidence for human health.
Read the paper
Related studies
- Calcium Ions in the Physiology and Pathology of the Central Nervous System
- AI-powered in silico twins: redefining precision medicine through simulation, personalization, and predictive healthcare
- In silico functional, structural and pathogenicity analysis of missense single nucleotide polymorphisms in human MCM6 gene
- In Silico drug repurposing pipeline using deep learning and structure based approaches in epilepsy
- Targeting serotonin receptors with phytochemicals – an in-silico study
- In silico exploration of anti-prostate cancer compounds from differential expressed genes
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.