Headache in Pregnancy: A Case Series of Secondary and Benign Causes with Diagnostic Pathways
Abstract
Headache during pregnancy and the postpartum period requires careful evaluation because physiological changes can
mask serious secondary causes. We present a case series of four obstetric patients with varied headache etiologies,
ranging from benign dehydration and migraine to secondary intracranial hypotension and cerebral venous sinus
thrombosis. Presentations occurred across antenatal and postnatal settings and included associated features such as
vomiting, bradycardia, and visual symptoms. Neuroimaging played a decisive role in differentiating primary from
secondary pathology, particularly MRI with venography in suspected venous thrombosis and characteristic structural
markers in intracranial hypotension. Management strategies differed substantially according to etiology, including
hydration therapy, migraine prophylaxis, and anticoagulation. Outcomes were favorable with timely multidisciplinary
involvement. This series underscores the importance of red-flag recognition, imaging selection, and coordinated
specialty care when evaluating headache in obstetric patients.
How strong is the evidence?
Evidence Hub reads this as a case series, done in people. Its evidence level is 5 of 5 (Very low · case / narrative / animal / in vitro / in silico). Case reports, narrative reviews, and animal, cell or computer-model studies give the weakest evidence for human health.
Read the paper
Related studies
- Calcium Ions in the Physiology and Pathology of the Central Nervous System
- AI-powered in silico twins: redefining precision medicine through simulation, personalization, and predictive healthcare
- In silico functional, structural and pathogenicity analysis of missense single nucleotide polymorphisms in human MCM6 gene
- In Silico drug repurposing pipeline using deep learning and structure based approaches in epilepsy
- Targeting serotonin receptors with phytochemicals – an in-silico study
- In silico exploration of anti-prostate cancer compounds from differential expressed genes
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.