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Treatment of abdominal migraine in an 8‐year‐old child with calcitonin gene‐related peptide receptor antagonist: A case report

Yun-Zhu Tang, Chunyan Lu, Yao Zhou, Shuxia Qian

Headache, 2025

Abstract

Episodic syndromes that may be associated with migraine, formerly called migraine equivalence syndrome, represent a spectrum of par - oxysmal disorders with pathophysiological links to migraine. They are recognized as prognostic factors for future migraine attacks, often preceding or accompanying classic migraine phenotypes. 1 Abdominal migraine (AM) is one of the episodic syndromes, defined by recurrent abdominal pain as the core symptom and frequently ac - companied by nausea, vomiting, and pallor, with each episode lasting several hours to several days. With advancing age, AM frequently progresses to a more typical form of migraine. In recent years, tar - geted therapy with calcitonin gene-related peptide (CGRP) recep - tor antagonists has achieved remarkable results in adult migraine; however, its application in pediatric AM remains unreported to date. This article reports a successful case of treating an 8- year-old girl with AM using rimegepant, a CGRP receptor antagonist, aiming to provide new insights for clinical practice. The child's guardian pro - vided written informed consent to authorize the publication of the patient's case and the disclosure of this case information. The patient

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