Intrathecal Administration of Ziconotide as a resolution of resistant chronic migraine. A case report
Abstract
Introduction: Chronic migraine (CM) is characterized by the recurrence of severe headache episodes accompanied by a cluster of symptoms that can have a significant impact on the quality of life of the patients. Case presentation: This is a case of a 46-year-old male with a history of resistant migraine and complex regional pain syndrome type II and sympathetically independent pain in the right lower leg, which started after fibula surgery. The patient exhibited increasing anxiety and depressive symptoms following the failure of multiple therapeutic interventions for CM and leg pain, and intrathecal ziconotide was recommended to treat the refractory complex regional pain syndrome. The patient reported a complete resolution of his migraine with ziconotide 2.0 g/day and 3.5 g/day for right lower leg pain. After 18 months of treatment with ziconotide via an intrathecal pump, the patient’s clinical condition continued to improve with a notable
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