Overview of β-Lactam-Resistance Genes in Pandemic Multidrug-Resistant Acinetobacter baumannii: A Troublesome Pathogen in the Indian Intensive Care Unit
Abstract
Acinetobacter baumannii is responsible for many infections in admitted patients, especially in the intensive care unit (ICU). Several risk factors may lead to an enhanced risk of A. baumannii colonization and infections. β-lactam antibiotics are frequently administered to treat Gram-positive and Gram-negative bacterial infections due to their minimum side effects, but the acquisition of β-lactamase genes has been the most challenging and troublesome situation and an imminent threat to the world as it increases mortality, medical expenses, and hospital stays. Hence, the present systematic review focused on the screening of β-lactam resistance genes that have been identified in the A. baumannii isolates’ genome and the nosocomial infections they cause in the Indian ICU.
This review has been done according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses guideline 2020. After screening, 317 genomes were included in this systematic review. We downloaded data from the bv-brc.org website on an Excel spreadsheet for statistical analysis. We presented categorical data in percentages (%) and in the form of a graph and pie chart.
Among the 317 isolates, pneumonia was caused by 189 strains (59.62%), bacteremia was caused by 109 strains (34.38%), respiratory infection by 12 isolates (3.79%), sepsis by 5 isolates (1.58%), and wound infection by 2 isolates (0.63%), which indicated that A. baumannii strains are highly involved in pneumonia followed by bacteremia. We…
Read the paper
Related studies
- Penicillins for Treatment of Pneumococcal Pneumonia: Does In Vitro Resistance Really Matter?
- Thiophenes—Naturally Occurring Plant Metabolites: Biological Activities and In Silico Evaluation of Their Potential as Cathepsin D Inhibitors
- Inhalable Mannosylated Rifampicin–Curcumin Co-Loaded Nanomicelles with Enhanced In Vitro Antimicrobial Efficacy for an Optimized Pulmonary Tuberculosis Therapy
- Development and validation of microbial bioassay for quantification of Levofloxacin in pharmaceutical preparations
- GC-MS Analysis and Biomedical Therapy of Oil from n-Hexane Fraction of Scutellaria edelbergii Rech. f.: In Vitro, In Vivo, and In Silico Approach
- Propranolol, chlorpromazine and diclofenac restore susceptibility of extensively drug-resistant (XDR)-Acinetobacter baumannii to fluoroquinolones
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.