Hyperacusis in vestibular migraine successfully treated with galcanezumab: A case report
Abstract
Background Hyperacusis, a heightened sensitivity to sound, can severely impair quality of life and remains difficult to treat. Case We report a 44-year-old woman with vestibular migraine who experienced persistent dizziness, tinnitus, and hyperacusis. Initial treatment with amitriptyline and traditional Kampo medicine improved her dizziness but not her auditory symptoms. Subsequently, galcanezumab, a calcitonin gene-related peptide (CGRP) monoclonal antibody, was administered monthly. Over six months, her Khalfa Hyperacusis Questionnaire score improved markedly from 21 to 3, and her headache impulse test-6 score decreased from 66 to 58. Conclusion This case demonstrates a potential role for CGRP-targeted therapy in treating migraine-associated hyperacusis and suggests a broader application in sensory modulation disorders. To our knowledge, this is the first report to describe the successful use of galcanezumab in hyperacusis, offering new insights into migraine-related auditory hypersensitivity. Graphical abstract This is a visual representation of the abstract.
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Evidence Hub reads this as a case report, done in people. Its evidence level is 5 of 5 (Very low · case / narrative / animal / in vitro / in silico). Case reports, narrative reviews, and animal, cell or computer-model studies give the weakest evidence for human health.
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