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Post-traumatic trigeminal injury leading to novel-onset orofacial migraine: A case report

P. Yakkaphan, Cattliya Laohapotjanart, Rosenee Adulbhakdee, S. Ruangsri, T. P. Jorns

Cephalalgia Reports, 2025

Abstract

Background Orofacial migraine has been increasingly recognized and described in literature. The presence of orofacial migraine could be due to the radiation of migraine headache to the facial area, the development of new isolated facial migraines, or the relocation of prior migraine headaches to the facial region following nerve trauma. Case This report presents a patient who developed a novel orofacial migraine after an injury to the trigeminal nerve caused by the surgical removal of an impacted tooth. Initially diagnosed as post-traumatic trigeminal neuropathy, the pain later evolved to exhibit migraine-like characteristics. The patient had no prior history of migraine or other primary headaches. While the possibility of “novel-onset” post-traumatic orofacial migraine has been proposed, no cases have been documented in the literature. Conclusion Recognizing post-traumatic migraine in the orofacial region suggests a potential association between trigeminal nerve injury and the onset of new orofacial migraine and underscores the importance of accurate diagnosis and treatment among orofacial pain conditions. Graphical abstract This is a visual representation of the abstract.

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