Evidence Hub

Two Rare Coexisting Diseases and an Uncommon Presentation: Migraine, and Neuromyelitis Optica Presented with Cervicogenic Headache - A Case Report

Berkcan Piset, Rabia Gokcen Gozubatik Celik

Journal of Multiple Sclerosis Research, 2025

1 citation

Abstract

Neuromyelitis optica (NMO) is a rare autoimmune disorder distinguished by optic neuritis, transverse myelitis, and area postrema syndrome. Headaches as an initial manifestation are uncommon and often overlooked. This case describes a 46-year-old female with a 20-year history of migraines. The patient developed cervicogenic headaches three years before presenting with optic neuritis. MRI findings of optic and spinal lesions, together with positive aquaporin-4 immunoglobulin G antibodies, corroborated the diagnosis of NMO. Treatment with intravenous methylprednisolone, azathioprine

How strong is the evidence?

Evidence Hub reads this as a case report, done in people. Its evidence level is 5 of 5 (Very low · case / narrative / animal / in vitro / in silico). Case reports, narrative reviews, and animal, cell or computer-model studies give the weakest evidence for human health.

How the five levels of evidence work. The level is assigned automatically from the abstract and can be wrong, so check the paper.

Read the paper

Related studies

Go deeper in Evidence Hub

Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.

Open this study Sign up free