Migraine headaches: What is new in treatment?
Abstract
Migraine is the most common acute and recurrent headache disorder in the pediatric population. Its management is typically divided into acute and preventive interventions. This article aims to review the current evidence for both therapeutic approaches in migraine, with a focus on emerging treatment options approved for adult use, and currently under investigation in children and adolescents. Both pharmacological and nonpharmacological strategies under study are discussed, including onabotulinumtoxinA, neuromodulation devices, gepants, monoclonal antibodies, and 5-hydroxytryptamine receptor agonists. To date, topiramate and propranolol have shown modest benefits compared to placebo. Although the evidence supporting the use of novel therapies in pediatric migraine is expanding, it remains limited and under development.
La migraña representa la cefalea aguda y recurrente más frecuente en pediatría. Su abordaje terapéutico está basado en intervenciones agudas y preventivas. El objetivo de este artículo es revisar la evidencia actual sobre ambos enfoques en el tratamiento de la migraña, con énfasis en las nuevas opciones terapéuticas aprobadas para adultos, que se encuentran en evaluación para su uso en niños y adolescentes. Se describen tanto estrategias farmacológicas como no farmacológicas, incluyendo toxina onabotulinumtoxinaA, dispositivos de neuromodulación, gepantes, anticuerpos monoclonales y agonistas del receptor 5-hidroxitriptamina. Hasta el momento, el topiramato y…
Read the paper
Related studies
- Calcium Ions in the Physiology and Pathology of the Central Nervous System
- AI-powered in silico twins: redefining precision medicine through simulation, personalization, and predictive healthcare
- In silico functional, structural and pathogenicity analysis of missense single nucleotide polymorphisms in human MCM6 gene
- In Silico drug repurposing pipeline using deep learning and structure based approaches in epilepsy
- Targeting serotonin receptors with phytochemicals – an in-silico study
- In silico exploration of anti-prostate cancer compounds from differential expressed genes
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.