Migraine and Dementia: A Narrative Review of Current Evidence
Abstract
Background: Migraine is a common neurological disorder characterized by recurrent headaches, while dementia is a progressive neurodegenerative condition leading to cognitive decline. Recent studies indicate that these conditions may share common underlying mechanisms, such as vascular dysfunction, Neuroinflammation, oxidative stress, and structural brain changes, all of which could contribute to cognitive impairment. The aim was to explore the potential connection between migraine, particularly migraine with aura, and an augmented risk of dementia. Material and Methods: the keywords Migraine, Dementia, Vascular Dysfunction, Neuroinflammation, Oxidative Stress, Cognitive Decline are used to search for articles in the PubMed and others databases for the period from 2000 to 2024. Conclusions: studies on the general population indicate that those who suffer from migraines, particularly those who have aura, may be more susceptible to dementia, including vascular and Alzheimer’s diseases. However, the results are inconclusive, and further research is needed to understand this potential link. Shared mechanisms like endothelial dysfunction, neuroinflammation, and oxidative stress provide evidence of a connection between migraine and dementia. This potential link has significant clinical implications. Patients with a history of migraine should have their mental health closely watched by medical professionals, especially if they experience frequent auras or chronic migraines.…
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