Comparative Effectiveness of Pharmacological versus Non-pharmacological Interventions for Migraine Management: A Meta-analysis
Abstract
Non-pharmacological interventions are increasingly explored as alternatives to pharmacological treatments for managing migraine, with the aim of reducing attack frequency and migraine days per month. This meta-analysis evaluates the efficacy of non-pharmacological interventions versus pharmacological treatments in addressing these parameters.
The present study conforms to the PRISMA guidelines for conducting systematic review and meta-analysis. An electronic search was conducted with PubMed, Scopus, Web of Science, and Cochrane Library databases for articles published between 2000 and 2024. RCTs that compare non-pharmacological and pharmacological treatments of migraine patients were included. Details of data extraction and analysis were done by two researchers, while statistical analysis was done using R 4.2.2. For continuous data, the mean differences with the corresponding 95% CIs and the I² statistic for heterogeneity were used.
A significant reduction in attack frequency per month was observed with non-pharmacological interventions compared to pharmacological treatments, as indicated by a negative mean difference (−0.2896) in the common effect model. However, the random effects model suggested greater variability in results, highlighting the need for nuanced interpretation. No statistically significant difference was found in migraine days per month between the two interventions, although observed heterogeneity underscores the importance of individualized approaches in…
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