Evaluation of Autonomic Dysfunction in Pediatric Migraine Patients
Abstract
Objective: Headache during childhood is a common condition. Although recent studies have shown that the autonomic nervous system (ANS) in adult migraine patients is affected, there are few studies evaluating this relationship in children. Adult migraine patients demonstrate no abnormal ANS function in either the sympathetic or parasympathetic nervous system but there can be sympathetic/parasympathetic hypofunction/hyperfunction. The aim of this study is to investigate autonomic dysfunction in pediatric migraine patients. Method: The study evaluated tests for autonomic functions such as the orthostatic test, 30: 15 ratio, cold-pressor test, heart-rate responses to deep and normal breathing, valsalva ratio (VR), blink reflex (BR), and sympatheticskin-response with thirty pediatric migraine patients in interictal period. Patients in control group were selected from children that had not any other disease or headhache. Results: Consistent with sympathetic hypofunction, there was more frequent orthostatic hypotension in migraine group (p=0.019) and negative correlation between average disease duration, migraine attack duration and orthostatic tests results. Consistent with parasympathetic hyperfunction, the migraine group had higher VRs (p=0.035). There was a negative correlation between analgesic use rate and normal respiratory-RR-interval variability and between attack rate and deep and normal-R-R interval (R-wave peak to R-wave peak in electrocardiograms) variability. There…
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