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Cefaly Neurostimulation Therapy For Intractable Migraine Patients

Mahdi Ahani, Pouya Karami, Tina Ehrami, Abdoreza Ghoreishi

Journal of Advances in Medical and Biomedical Research, 2025

20 participants

Abstract

Background & Objective: Migraine is a common neurological disorder affecting one billion people worldwide, causing disability, reduced quality of life, and high economic costs.Medical treatments have often limited efficacy and side effects.Non-pharmacological options such as trigeminal nerve stimulation with devices such as Cefaly® offer alternatives.This study assesses effectiveness of Cefaly®'s in reducing uncontrolled migraine symptoms alongside standard medications. Materials & Methods:This study included 20 patients with migraine, with or without aura, intractable to conventional treatments.Participants used the Cefaly® device in addition to regular medication for external trigeminal nerve stimulation on the forehead.Migraine frequency, severity, and duration were assessed over one month using pre-and post-intervention questionnaires, with data analyzed by nonparametric methods due to the small sample size.Results: The proportion of participants experiencing severe attacks dropped from 45% to 15% (P = 0.037).The frequency of attacks was reduced, with the percentage of participants having 3-5 attacks per month falling from 75% to 45%, and those with more than 5 attacks per month declining to 0% (P = 0.038).Attack duration also decreased, with a reduction in attacks lasting 12-24 hours from 35% to 20%, and those lasting more than 24 hours from 45% to 15% (P = 0.002).Conclusion: Cefaly® could effectively reduce the severity, frequency, and duration of headaches in patients…

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