Conjunctival Impression Cytology and Dry Eye Parameters in Migraine Patients
Abstract
INTRODUCTION/BACKGROUND: Migraine is a chronic neurovascular inflammatory disorder involving complex mechanisms such as trigeminovascular system activation and neuroinflammation. In addition to headache, migraine may be associated with ophthalmic manifestations that are often overlooked. Dry eye disease is a multifactorial inflammatory disorder of the ocular surface characterized by tear film instability. Recent evidence suggests a potential association between migraine and dry eye, possibly through shared neurovascular and inflammatory pathways. OBJECTIVE: In this study, it was aimed to compare ocular surface changes and dry eye parameters between migraine patients and healthy individuals. METHODS AND MATERIALS: The participants of the present cross-sectional comparative study are 30 migraine patients and 31 age and gender matched healthy individuals. The demographic and clinical data of migraine patients were recorded. Ocular surface changes were evaluated using Schirmer I test, tear break-up time (TBUT), Ocular Surface Disease Index (OSDI) scores and conjunctival impression cytology (CIC) grades were assessed and results were compared between the two groups. RESULTS: CIC degrees of the migraine patients were higher than the control group (p<0.001). CIC assessment of the migraine group revealed that ten patients (33.3%) were of grade II-III, whereas the CIC assessment of two (6.5%) participants in the control group was grade II. Grade III CIC was not determined in the…
How strong is the evidence?
Evidence Hub reads this as a cross-sectional, done in people. Its evidence level is 4 of 5 (Low · observational). Observational designs can show an association but not prove cause. Reported size: 30 participants or records.
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