Cardiovascular responses to tilting in female migraine patients with impaired autonomic reaction
Abstract
Background: Orthostatic hypotension (OH) is the second most common cause of syncope, prevalent in migraine patients. Objective: To assess the cardiovascular responses to tilt test in female migraine patients. Methods: This experimental study was conducted on 70 newly diagnosed female migraine patients (age 15–30 years & BMI 18.2-26.59kg/m²). Among them, 20 migraine patients were with normal (group MN) and 20 patients had impaired autonomic reaction (group MI). Twenty (20) apparently healthy subjects with similar age and BMI were also enrolled as control. Autonomic reactivity of all participants was assessed by conventional autonomic function test (CAFT). Head Up Tilt Test (HUTT) of all subjects was done by tilting 600 for 10 min using a motorized tilt table. Cardiovascular responses to tilting were observed by change in Heart rate (Acceleration index and Brake index); change in systolic blood pressure (SBP30s-0 and SBP1min-0); change in diastolic blood pressure (DBP30s-0 and DBP1min-0), after the tilting from supine position. Data were analyzed using one-way ANOVA followed by Bonferroni’s post hoc test. Results: In this study, the Acceleration index was significantly lower in Group MI compared to Group MN (p≤0.001) and control (p≤ 0.01). But the Brake index was significantly lower (p≤0.05, p≤0.01) in both group of patients than control. Again no significant difference found in Brake index between Group MN and Group MI. SBP30sec-0 was significantly higher in both of the…
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