Comparison of pentraxin-3 in migraine patients without auraand healthy controls
Abstract
AbstractBackground and Objectives: Migraine is a common cerebrovascular conditionmarked by one-sided, pulsatingheadache, which may or may not be accompanied with an aura. Migraine is mostly found in females who areof childbearing age. One of the speculated mechanisms for the pathophysiology of migraine is endothelialdysfunction.Anew biomarker of inflammatory disorders, pentraxin-3 is often produced by endothelium injury.In earlier investigations, it was shown that migraine sufferers had elevated levels of pentraxin-3. Our study'sobjectiveswere toanalyze the serumpentraxin-3levelsinmigraine suffererswithout aura and healthycontrols.Methods: It was a cross-sectional comparative study. This was done at the IMBB Department, University ofLahore, Lahore Pakistan, from March 2020 to April 2022. We took 40 diagnosed migraine cases and 40healthy controls. Detailed examination was done and proformas were filled by both cases and controls. Serumwas collected by each of them and pentraxin-3 values were determined by using specific Elisa kits. SPSSversion 22 was used for statistical analysis. For normality of data Shapiro wilk test was used. Mann whiteny Utest was used for the comparision of means of pentraxin-3 in migrainers and healthy controls.Results: The data were non-normally distributed after the Shapiro-Wilk Test. The average age of the controlswas 25±6.06 years, while that of individuals with migraines was 26±7.78 years. Patients with migraine weremostly women. The majority of…
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Evidence Hub reads this as a cross-sectional, done in people. Its evidence level is 4 of 5 (Low · observational). Observational designs can show an association but not prove cause.
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