The Second Exteroceptive Suppression Period of the Temporalis Muscle Is Altered in Migraine Patients With Allodynia
Abstract
Background/Objectives The study of the second exteroceptive suppression period (ES2) of the temporalis muscle could provide information as to the brainstem neural circuits involved in migraine pathophysiology. Allodynia is known to be related to the sensitization of second/third order neurons in the trigeminal nucleus caudalis and sensory thalamus, respectively. The aim of this observational, pilot study was to investigate the ES2 of the temporalis muscle in female migraineurs, with and without allodynia, in the interictal period, compared to controls. Methods A total of 49 non-consecutive female patients fulfilling the diagnostic criteria for migraine (13 with aura, 26 episodic 23 chronic), naïve from any pharmacological prophylactic treatment, without relevant comorbidities and 19 healthy controls were enrolled. The exteroceptive suppression of the temporalis muscle activity was registered, according to international standards, in the interictal period. The presence of allodynia was assessed by the Allodynia Symptom Checklist. Results Twenty-four patients (50%) had allodynia, 16/24 (67%) were chronic migraineurs. The ES2 latency and duration between the groups were compared by the Student’s t-test. There were no statistically significant differences in the ES2 latency or its duration between the migraine patients and controls. Conversely, the ES2 duration was significantly longer in allodynic migraineurs than in controls (p=0.04) and in allodynic than in non-allodynic…
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