The Effects of Topiramate and Flunarizine on serum Glutamine and neuropeptide Y levels in adolescent Rats with a Migraine model
Abstract
This study aimed to investigate the effects of topiramate and flunarizine on serum glutamine and neuropeptide Y (NPY) levels in adolescent (6 weeks) rats with a migraine model induced by trinitroglycerin (NTG). For this purpose, 48 Wistar albino male rats in the adolescent stage were used. The rats were divided into 6 groups, each consisting of 8 animals. Group 1 (n=8): Healthy control group; no agent was applied. Group 2 (n=8): Migraine group; NTG (10 mg/kg, IP) was administered once daily. Group 3 (n=8): Migraine + Topiramate group; NTG (10 mg/ kg, IP) was administered once daily, and topiramate (50 mg) was administered orally twice a day. Group 4 (n=8): Migraine + Flunarizine group; NTG (10 mg/kg, IP) was administered once daily, and flunarizine (5 mg) was administered orally twice a day. Group 5 (n=8): Topiramate group only; topiramate (50 mg) was administered orally twice a day. Group 6 (n=8): Flunarizine group only; flunarizine (5 mg) was administered orally twice a day. All applications were performed for 5 days. In the migraine-induced group, a significant increase in glutamine and NPY levels was observed compared to the control group. However, in the topiramate and flunarizine groups (grup 5 and 6), no significant differences were detected in these levels compared to the control group. The NTG application was found to be suitable for creating a migraine model, but to observe better clinical findings, an increase in both dose and duration may be necessary. It was…
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