Formulation and In-vitro Characterisation of nasal In-Situ Gel for treatment of Anti-migraine Drug
Abstract
The present study aimed to develop and evaluate a temperature-dependent nasal in situ gel of Rizatriptan benzoate for enhanced nasal residence time and improved bioavailability in migraine therapy. Rizatriptan benzoate undergoes extensive first-pass metabolism, resulting in low oral bioavailability. To overcome this limitation, a thermosensitive nasal in situ gel system was prepared using polymers such as Chitosan HCl, Sodium β-Glycerophosphate, Sodium alginate, and Gellan gum. The formulations were evaluated for physicochemical parameters including pH, gelation temperature, viscosity, mucoadhesive strength, drug content, and in vitro drug release. The optimized formulation FF5 showed satisfactory gelation at nasal temperature, good mucoadhesion, and sustained drug release over 8 hours. Drug release kinetics revealed diffusion-controlled release following the Higuchi model. Stability studies indicated that the optimized formulation remained stable under different storage conditions. The developed temperature-dependent nasal in situ gel demonstrated potential as an effective and patient-friendly approach for sustained nasal delivery of Rizatriptan benzoate.
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