Migraine in women undergoing fertility treatment: A prospective study
Abstract
OBJECTIVE: To determine if there is increased headache burden and disability among women with and without migraine during an in vitro fertilization (IVF) cycle. BACKGROUND: Migraine and infertility commonly impact women of childbearing age. Estradiol fluctuations influence migraine, yet the impact of exogenous estrogen on migraine during fertility treatments such as IVF is not well characterized. We assessed migraine burden and disability among women with and without a history of migraine during an IVF cycle. Secondary outcomes included psychological symptoms and estradiol levels. We hypothesized that although all women may be at risk of migraine symptoms during an IVF cycle, women with migraine would be more likely to experience greater headache-related disability and associated psychological symptoms during an IVF cycle. Furthermore, we hypothesized that women with migraine would experience an increase in headache-related disability between time point 2 (when estrogen peaks after ovulation trigger) and time point 3 (when estradiol levels reach a nadir). Women without a history of migraine were included to assess the development of de novo migraine during IVF due to shifts in estradiol. METHODS: A prospective cohort study of adult women undergoing an IVF cycle at the Weill Cornell Medicine Center for Reproductive Medicine (New York, NY) from 2020 to 2023 completed an initial health questionnaire and follow-up throughout an IVF cycle at three time points. Data collected…
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Evidence Hub reads this as a cohort study, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence.
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