Autotaxin as a novel biomarker of migraine
Abstract
Abstract Background Migraine is the most common neurological disorder and the second most disabling human condition. As Autotaxin (ATX) may be a link between common mechanisms associated with migraine, we aimed to test its role as a novel biomarker of migraine. Methods In this cross-sectional study, healthy controls (n = 68), episodic migraine (EM) (n = 45), and chronic migraine (CM) patients (n = 38) were studied. Clinical outcomes, such as Visual Analogue Scale (VAS), frequency of headaches (days/month), evolution time (months) and the crisis of attacks (hours); as well as serum biomarkers for inflammation (interleukin-6, [IL-6], and interleukin-10 [IL-10]), trigeminovascular system activation (calcitonin gene-related peptide, [CGRP]), endothelial dysfunction (pentraxin-3, [PTX-3], cellular fibrinogen [cFn], soluble tumor necrosis factor-like weak inducer of apoptosis [sTWEAK]), and ATX, were investigated. Additionally, the serum lipidomic biomarkers profile was also performed. Results Serum ATX levels were found to be significantly elevated in both EM (310.7 ± 79.69 ng/mL) and CM (336.7 ± 66.93 ng/mL) compared to controls (212.3 ± 53.19 ng/mL) (p < 0.0001). Elevated ATX levels were associated with migraine outcomes in CM (VAS, frequency, evolution time and crisis duration). ATX was correlated with CGRP, PTX3, sTWEAK, Fn; and IL-6. A drastic decrease in serum lysophosphatidylcholine (LPC) levels indicates high ATX activity in migraine. Conclusions Serum levels of ATX were…
How strong is the evidence?
Evidence Hub reads this as a cross-sectional. Its evidence level is 4 of 5 (Low · observational). Observational designs can show an association but not prove cause. Reported size: 68 participants or records.
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