Formulation and Characterization of Transdermal Patches for Controlled Delivery of Fravotriptan for the Treatment of Migraine
Abstract
The present study focuses on the formulation and characterization of transdermal patches for the controlled delivery of Fravotriptan, a selective 5-HT1B/1D receptor agonist used in the treatment of migraine. Due to its short half-life and extensive first-pass metabolism, the oral delivery of Fravotriptan often results in reduced bioavailability and frequent dosing. To overcome these limitations, transdermal drug delivery systems (TDDS) offer a promising alternative by maintaining sustained drug release, enhancing patient compliance, and minimizing systemic side effects. In this research, transdermal patches were formulated using varying concentrations of hydrophilic (HPMC E15) and hydrophobic Ethyl cellulose and Eudragit RL100, EC) polymers through the solvent casting method. Polyethylene glycol 400 (PEG-400) was employed as a plasticizer to improve flexibility and mechanical strength. The prepared patches were subjected to various physicochemical evaluations, including thickness, weight uniformity, folding endurance, tensile strength, moisture content, moisture uptake, drug content uniformity, pH, and in vitro drug release studies using Franz diffusion cells.Among all the formulations, the optimized patch demonstrated uniform thickness, high folding endurance, suitable drug content, and sustained drug release up to 12 hours, following Higuchi kinetics, suggesting a diffusion-controlled release mechanism. The optimized patch also exhibited good physical stability during…
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