Formulation and characterization of fast dissolving oral films of rizatriptan for effective treatment of migraine
Abstract
Migraine is a common neurological disorder requiring rapid onset of action for effective management. The present study aimed to formulate and characterize fast dissolving oral films of Rizatriptan to improve patient compliance and provide quick relief. Fast dissolving oral films (F1–F6) were prepared using suitable film-forming polymers and evaluated for physicochemical and mechanical properties. All formulations showed acceptable appearance, thickness, and weight uniformity. Folding endurance, tensile strength, moisture content, disintegration time, and drug content were found to be within acceptable limits. Among all formulations, F5 exhibited superior characteristics, including highest folding endurance (240 ± 4), lowest disintegration time (50 ± 3 seconds), and maximum drug content (99.00 ± 0.26%). The in vitro drug release study of optimized formulation F5 showed rapid release, with 47.12% drug release within 1 minute and 99.12% release within 15 minutes, indicating its suitability for immediate therapeutic action. Stability studies confirmed that the formulation remained stable over a period of three months with minimal variation in drug content. In conclusion, the developed fast dissolving oral film of rizatriptan offers a promising alternative to conventional dosage forms by providing rapid drug release, improved patient compliance, and effective management of migraine. Keywords: Rizatriptan, Fast dissolving oral film, Migraine, Solvent casting method, Rapid drug…
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