Synthesis of (S)-(+)-Dapoxetine
Abstract
Significance ( S )-(+)-Dapoxetine (Priligy ® ) is a potent selective serotonin reuptake inhibitor with a short half-life that is used to treat premature ejaculation. The key step in the asymmetric synthesis shown is an asymmetric C-H amination catalyzed by Rh 2 ( R -nap) 4 .
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