Synthesis of dapoxetine hydrochloride
Abstract
Objective: To synthesize dapoxetine hydrochloride.Methods: Dapoxetine hydrochloride was synthesized from benzaldehyde and malonic acid via eight steps.Results: The chemical structure of the target compound was confirmed by 1H NMR,13C NMR and 2D-NMR analyses.The total yield of the target compound was 15.08%.Conclusion: This synthesis is an easily manipulated synthetic process with high yield,and it is also suited for industrialization.
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