Synthesis of Dapoxetine Hydrochloride
Abstract
Dapoxetine hydrochloride was synthesized from 3-chloropropiophenone by catalytic asymmetric reduction,alkylation,O-methlsulfonylation,SN2 dimethylamination,as well as salt formation in an overall yield of 39.9%.The structure was confirmed by 1H NMR and MS.
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