Validated UV -spectrophotometric method for estimation of dapoxetine
Abstract
,cost effective, reproducible and accurate UV-spectrophotometric method was ultraviolet region for the estimation of Dapoxetine in pure drug, pharmaceutical formulation. Linear response obtained was in the concentration range of 10-50 µ g/ml in solvent. Excellent recovery proved that method was sufficiently accurate. There is no interference from any common pharmaceutical additives and diluents. Results of analysis were validated by recovery studies according to ICH Q2(R1) guidelines. Spectrophotometry , Validaton. N,N -[dimethyl-3-(naphthalen-1-yloxy)-1-phenylpropan-1-amine] oxetine is a white colored Powder with molecular mass of 305.413 partially soluble in water and greatly soluble in methanol. It is a short-acting selective reuptake inhibitor the only drug with regulatory appro val for the treatment of premature ejaculation in men .Analysis is an important c omponent in the formulation development of any drug molecule. A suitable vailable for the analysis of drug (s) in bulk, in drug delivery systems. (Hamilton and Cornpropst,2002) methods are available for the estimation of The authors now propose a new validated, sensitive and reproducible UV-Spectropho tometric method and the Tablet dosage forms was also observed. The information about were not reported in literature. An attempt has been made to develop simple, sensitive, and economical method in UV region with greater precision and accuracy for the estimation of Dapoxetine
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