Immune-Related Adverse Events and Survival Among Patients With Metastatic NSCLC Treated With Immune Checkpoint Inhibitors
Abstract
Key Points Question Are immune-related adverse events associated with improved overall survival in patients with locally advanced or metastatic non–small cell lung cancer receiving immune checkpoint inhibitor (ICI) therapy? Findings In this cohort study of 803 patients, developing an immune-related adverse event mandating delay or discontinuation of ICI therapy and/or systemic corticosteroids for management of toxic effects was associated with significantly improved median overall survival. This association was not compromised by hospitalization for management of toxic effects of severe immune-related adverse events. Meaning These findings suggest that immune-related adverse events are associated with improved overall survival in patients receiving ICI therapy, even in the context of hospitalization for management of toxic effects.
How strong is the evidence?
Evidence Hub reads this as a cohort study, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence. Reported size: 803 participants or records.
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