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Adropin modulates pancreatic cell proliferation and glutathione levels in an animal model of type 1 diabetes mellitus

I. I. Ali, Crystal M D'Souza, A. Nemmar, S. Ojha, E. Adeghate

Animal Models and Experimental Medicine, 2025

Abstract

Diabetes mellitus (DM), a metabolic disorder that leads to chronic hyperglycemia, is one of the topmost global public health concerns according to the International Diabetes Federation. Adropin is a peptide hormone that is primarily involved in energy homeostasis, but its involvement in other biological activities such as lowering hyperlipidemia, and diminishing insulin resistance has also been reported. In this study, we aimed to explore additional effects of adropin on oxidative stress, inflammation, and cell proliferation in an animal model of type 1 DM.

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