Investigating the Synergistic Potential of Combination of Natural Penetration Enhancers and a Synthetic Drug in Animal Model for Improved Transdermal Delivery
Abstract
Background: The aim of current investigation was to analyze synergistic effect of natural penetration enhancers in combination with a synthetic drug in an animal model to enhance transdermal drug delivery. Methods: Initially, while carrying out the work in 2021-23 trial formulation batches were prepared with different penetration enhancers and then these were undergone through optimization study to optimize various parameters. A 32 full factorial design was utilized for study of optimization. An appropriate animal model was selected to analyze anti-inflammatory and analgesic effect of product. Statistical analysis was doneby utilizing one-way ANOVA, post hoc Tukey-Kramer test utilizing GraphPad Prism 9. Value of p less than 0.05 wasdeemed considerable. Result: It was concluded from the study that reduction in paw licking activity was approximately found to be 69.52, 72.32 and 74.10 % with Emulgel 1, Emulgel 2 and Emulgel 3, compared with group of control (p less than 0.05 vs control). These findings showed that the analgesic effect of all three formulations was promising. Emulgel 3 i.e., Sapindus mukorossi showed better anti-inflammatory activity in comparison to Allium sativum and Zingiber officinale.
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