Aortic valve disease: Novel animal models for advancing our understanding of the underlying mechanisms
Abstract
Abstract The global public health burden of aortic valve disease (AVD) is growing due to its high mortality rate and lack of suitable pharmaceutical therapies in clinical practice, a challenge that is largely attributable to our poor understanding of its complicated underlying mechanisms. A better understanding of the pathological processes underlying AVD is urgently needed to identify novel therapeutic options. Appropriate animal models are emerging as vital tools for basic and translational research, and the development of new models and the important information they have provided has significantly aided our research. However, different animal models have unique limitations in their ability to mimic human AVD pathology. In this review, we summarize the available AVD animal models and provide a detailed description of the major principles underlying each animal model, including methodology, pathological features, and potential use and application in AVD research. Both the advantages and disadvantages of specific models are also carefully highlighted; thus this comprehensive review provides a valuable animal model reference for both basic and preclinical researchers.
How strong is the evidence?
Evidence Hub reads this as a review, done in animal, not in people. Its evidence level is 5 of 5 (Very low · case / narrative / animal / in vitro / in silico). Case reports, narrative reviews, and animal, cell or computer-model studies give the weakest evidence for human health.
Read the paper
Related studies
- Improving the translation of search strategies using the Polyglot Search Translator: a randomized controlled trial
- Nutritional, Physical, Cognitive, and Combination Interventions and Frailty Reversal Among Older Adults: A Randomized Controlled Trial
- Clinical characteristics and risk factors associated with COVID-19 severity in patients with haematological malignancies in Italy: a retrospective, multicentre, cohort study
- A randomized, controlled trial of oral propranolol in infantile hemangioma
- Clinical phenotypes of delirium during critical illness and severity of subsequent long-term cognitive impairment: a prospective cohort study
- Increased physical activity improves sleep and mood outcomes in inactive people with insomnia: a randomized controlled trial
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.