KH-001 delays para-chloroamphetamine-induced ejaculation in anaesthetized rat
Abstract
Premature ejaculation (PE) is one of the most common male sexual dysfunctions, with a lifetime prevalence of ~20% and only 9% of affected men seeking medical attention.1 Diagnostic definitions from the DSM-5 and the International Society for Sexual Medicine describe PE as ejaculation occurring consistently within ~1 min for lifelong PE or ~3 min for acquired PE, accompanied by an inability to delay ejaculation and significant personal or interpersonal distress based on established clinical guidelines.2 The condition has a substantial psychosocial impact: men report reduced self-esteem and increased distress, while partners experience sexual dissatisfaction, frustration, and relationship strain. Despite its prevalence and burden, available treatment options are limited. Off-label daily selective serotonin reuptake inhibitors (SSRIs) and on-demand dapoxetine have high discontinuation rates, are widely used but only modestly effective, are associated with undesirable side effects, and have low long-term adherence. Notably, there is still no US-approved medication for PE. These limitations highlight the need for new pharmacological approaches. The para-chloroamphetamine (PCA)–induced ejaculation model is a well-established method for studying ejaculatory physiology and pharmacological modulation in rats.3 PCA is an amphetamine derivative that induces release of serotonin and catecholamines, reliably triggering ejaculation in conscious and anaesthetized rodents.3 Ejaculation is a…
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