Clinical application study of neuromuscular electrical stimulation for premature ejaculationEstudio de aplicación clínica de la estimulación eléctrica neuromuscular para la eyaculación prematura
Abstract
Premature ejaculation (PE) is a highly prevalent male sexual dysfunction that significantly impairs psychological well-being, interpersonal relationships, and quality of life. Although pharmacological treatments, such as selective serotonin reuptake inhibitors and topical anesthetics, remain the mainstay of therapy, their clinical effectiveness is often limited by adverse effects, suboptimal efficacy, and poor long-term adherence. In recent years, neuromuscular electrical stimulation (NMES) has emerged as a potential non-pharmacological therapeutic option for PE, attracting increasing clinical and research interest. This narrative review provides a comprehensive overview of the neurophysiological mechanisms underlying ejaculation and the pathophysiology of PE, with a particular focus on the theoretical rationale and clinical evidence supporting NMES therapy. We summarize findings from available animal experiments and human clinical studies evaluating low-frequency electrical stimulation, highlighting its effects on intravaginal ejaculatory latency time, ejaculatory control, and patient-reported outcomes. In addition, we discuss the proposed peripheral and central mechanisms of action of NMES, including modulation of pelvic floor muscle activity, alteration of penile sensory thresholds, regulation of autonomic nervous system balance, modulation of spinal and supraspinal reflex pathways and neurotransmitter signaling, and improvement of pelvic microcirculation. Integrative…
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Evidence Hub reads this as a randomized trial, done in people. Its evidence level is 2 of 5 (High · randomized trial). Randomized trials of a reasonable size are the strongest single-study design.
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