A novel topical GEL of the fresh young coconut husk ethanolic extract dedicated for diabetic wound healing
Abstract
Objective: This study aimed to develop and to optimize the formulation of novel Fresh-Young Coconut-Husk-Ethanolic-Extract (FYCHEE) gels by Response Surface Methodology (RSM) of a Box Behnken Design (BBD), and to investigate the activity of novel FYCHEE topical gels on accelerating the Diabetic Wound Healing (DWH). Methods: The FYCHEE was prepared by maceration using 96% ethanol and was standardized. Gels were formed by incorporating the FYCHEE into the gel-forming system containing Diethylene-Glycol Monoethyl-Ether (DGME), Carbopol 940, and Triethanolamine (TEA). Sixteen experimental runs were set using BBD. Physical properties (viscosity, pH and spread ability) were further characterized. The data were analyzed and optimized using “rsm” package of the R software. The predicted model of DGME, Carbopol 940 and TEA composition was further validated. The in vivo study of the activity of FYCHEE gels on accelerating DWH was conducted on groups of male Wistar rats in 12 d of topical application of FYCHEE gels containing 5%, 10%, 20% extracts. Results: The FYCHEE gels performed light-brown semisolid texture with varied physical characteristics. The RSM generated visualization of response surface plots based on three model equations. The novel FYCHEE gels with optimum responses have been well developed (DGME: Carbopol 940: TEA = 8:0.8:0.6). The formulation based on predicted composition showed 1.194±0.136 Pa. s (viscosity), 5.715±0.213 (pH) and 4.997±0.265 cm (spread-ability). The…
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