Assessment of cytotoxicity and growth inhibitory effects of methanol extract of Ageratum conyzoides linn
Abstract
Introduction: Evaluating cellular cytotoxicity is a crucial step in the development of specific anticancer therapies. As a medicinal plant, Ageratum conyzoides is well-known for its abundance of bioactive constituents, anti-inflammatory and anti-bacterial properties. In this study, its effect was evaluated to confirm if its methanol extract exhibits cytotoxic and growth-inhibitory properties, with potential relevance to oncology. Materials and Methods: Extraction of 1000 g of dried leaf material with methanol yielded 100 g of crude extract (10 %), indicating a high content of methanol-soluble bioactive compounds. The cytotoxic potential of the extract was assessed using Ranicep ranninus tadpoles as a preliminary model. Results: The study's findings demonstrated a clear concentration-dependent increase in mortality, with significant effects observed at 160 and 320 μg/mL and a moderate LC50 value of 100.76 μg/mL, confirming the extract's capacity to impair cell viability. Additionally, the extract exhibited significant inhibitory effects on the radicle growth of Sorghum bicolor, with both dose- and time-dependent responses. Higher concentrations (8 -16 μg/mL) and prolonged exposure periods resulted in marked suppression of radicle elongation, as reflected by percentage inhibition and IC50 values. Conclusion: These findings suggest that the extract can interfere with cell division and proliferation, processes analogous to those driving uncontrolled growth in cancer cells.…
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